Hello.
Since I had my last stroke in November 2024 I've been taking 80mg atorvastatin each day. I've also gained 15 unwanted kg since then. Research shows that atorvastatin reduces/depletes the body's Leptin. And Leptin deficiency causes weight gain. So I feel like it's a vicious circle. I take atorvastatin to reduce cholesterol yet it also promotes weight gain hence enhancing heart conditions.
What can I do. ?
Hello Gillian,
Thank you for reaching out on EnableMe.
I am sorry to hear of your stroke, and the weight gain you’ve been experiencing since commencing on the new statins. It can be challenging and frustrating when you are following what your Dr’s have recommended but are having unexpected changes which may also impact on your stroke risk factors.
You are right Gillian, there is some research that indicates that statins are associated with weight gain, but the reasons aren't clear. Although leptin may play a role, more research is needed to figure out what happens in living, breathing (and eating) humans.
What we do know for certain is that statins reduce the risk of stroke, so even if they're causing weight gain, they should still be beneficial. Given we are not medical here at StrokeLine, we would recommend you speak with your GP about weight gain, and safe ways to manage weight loss, in addition to taking your statin. Being overweight is a risk factor for stroke, but the impact of increased weight is often about its effect on factors such as cholesterol and blood pressure. If these risk factors are improving for you, then the weight gain isn't the biggest risk. Saying that, it is still important to try and maintain a healthy weight, not only to reduce the risk of stroke and heart attack, but also for your general health and well being.
It would be helpful to go and speak with your GP Gillian, and make sure that you know your numbers for your blood pressure and your cholesterol levels. Your GP can provide you with more information and support regarding your current weight gain.
If you would like more information or just to talk, do reach out to StrokeLine on Ph 1800 787 653, or email on strokeline@strokefoundation.org.au. We would be more than happy to talk with you in more detail.
Warm regards
Siobhan (StrokeLine)